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Development of the titanium–TADDOLate-catalyzed asymmetric fluorination of β-ketoesters

Titanium-based Lewis acids catalyze the α-fluorination of β-ketoesters by electrophilic N–F-fluorinating reagents. Asymmetric catalysis with TADDOLato–titanium(IV) dichloride (TADDOL = α,α,α',α'-tetraaryl-(1,3-dioxolane-4,5-diyl)-dimethanol) Lewis acids produces enantiomerically enriched α...

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書目詳細資料
Main Authors: Hintermann, Lukas, Perseghini, Mauro, Togni, Antonio
格式: Artigo
語言:Inglês
出版: Beilstein-Institut 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201056/
https://ncbi.nlm.nih.gov/pubmed/22043253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.7.166
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