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Enantio-, Diastereo- and Regioselective Iridium-Catalyzed Asymmetric Allylic Alkylation of Acyclic β-Ketoesters

The first regio-, diastereo- and enantioselective allylic alkylation of acyclic β-ketoesters to form vicinal tertiary and all-carbon quaternary stereocenters is reported. Critical to the successful development of this method was the employment of iridium catalysis in concert with N-aryl-phosphoramid...

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Detalhes bibliográficos
Main Authors: Liu, Wen-Bo, Reeves, Corey M., Stoltz, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881553/
https://ncbi.nlm.nih.gov/pubmed/24160327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4097829
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