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Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism
BACKGROUND: Celecoxib (Celebrex), a widely prescribed selective inhibitor of cyclooxygenase-2, can modulate ion channels independently of cyclooxygenase inhibition. Clinically relevant concentrations of celecoxib can affect ionic currents and alter functioning of neurons and myocytes. In particular,...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3200315/ https://ncbi.nlm.nih.gov/pubmed/22039467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026344 |
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