Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species Level, Mitochondrial Dysfunction, Caspase Activation, and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide

Epoxyeicosatrienoic acids (EETs) and the cytochrome P450 epoxygenase CYP2J2 promote tumorogenesis in vivo and in vitro via direct stimulation of tumor cell growth and inhibition of tumor cell apoptosis. Herein, we describe a novel mechanism of inhibition of tumor cell apoptosis by EETs. In Tca-8113...

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Detalhes bibliográficos
Main Authors: Liu, Liu, Chen, Chen, Gong, Wei, Li, Yuanjing, Edin, Matthew L., Zeldin, Darryl C., Wang, Dao Wen
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Cellular and Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199997/
https://ncbi.nlm.nih.gov/pubmed/21846841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180505
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