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Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species Level, Mitochondrial Dysfunction, Caspase Activation, and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide

Epoxyeicosatrienoic acids (EETs) and the cytochrome P450 epoxygenase CYP2J2 promote tumorogenesis in vivo and in vitro via direct stimulation of tumor cell growth and inhibition of tumor cell apoptosis. Herein, we describe a novel mechanism of inhibition of tumor cell apoptosis by EETs. In Tca-8113...

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Hlavní autoři: Liu, Liu, Chen, Chen, Gong, Wei, Li, Yuanjing, Edin, Matthew L., Zeldin, Darryl C., Wang, Dao Wen
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199997/
https://ncbi.nlm.nih.gov/pubmed/21846841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180505
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