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Immunochemical Detection of Cytochrome P450 Enzymes in Liver Microsomes of 27 Cynomolgus Monkeys

The cynomolgus monkey is widely used as a primate model in preclinical studies because of its evolutionary closeness to humans. Despite their importance in drug metabolism, the content of each cytochrome P450 (P450) enzyme has not been systematically determined in cynomolgus monkey livers. In this s...

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Bibliografiske detaljer
Main Authors: Uehara, Shotaro, Murayama, Norie, Nakanishi, Yasuharu, Zeldin, Darryl C., Yamazaki, Hiroshi, Uno, Yasuhiro
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199985/
https://ncbi.nlm.nih.gov/pubmed/21849623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.185009
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