Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

BACKGROUND: Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect. One strategy targeting this metabolic phenotype is glucose restriction by administration of a high-fat, low-carbohydrate (ketogenic) diet. Un...

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Main Authors: Maurer, Gabriele D, Brucker, Daniel P, Bähr, Oliver, Harter, Patrick N, Hattingen, Elke, Walenta, Stefan, Mueller-Klieser, Wolfgang, Steinbach, Joachim P, Rieger, Johannes
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199865/
https://ncbi.nlm.nih.gov/pubmed/21791085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-315
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