A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

BACKGROUND: KRAB-ZFPs (Krüppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effectors responsible for the formation of facultative hete...

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Autori principali: Meylan, Sylvain, Groner, Anna C, Ambrosini, Giovanna, Malani, Nirav, Quenneville, Simon, Zangger, Nadine, Kapopoulou, Adamandia, Kauzlaric, Annamaria, Rougemont, Jacques, Ciuffi, Angela, Bushman, Frederic D, Bucher, Philipp, Trono, Didier
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199781/
https://ncbi.nlm.nih.gov/pubmed/21791101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-12-378
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