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Mouse Inscuteable Induces Apical-Basal Spindle Orientation to Facilitate Intermediate Progenitor Generation in the Developing Neocortex

Neurons in the mammalian neocortex arise from asymmetric divisions of progenitors residing in the ventricular zone. While in most progenitor divisions, the mitotic spindle is parallel to the ventricular surface, some progenitors reorient the spindle and divide in oblique orientations. Here, we use c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Postiglione, Maria Pia, Jüschke, Christoph, Xie, Yunli, Haas, Gerald A., Charalambous, Christoforos, Knoblich, Juergen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199734/
https://ncbi.nlm.nih.gov/pubmed/22017987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.09.022
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