Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis

P53 inactivation is often observed in Burkitt's lymphoma (BL) cells due to mutations in the p53 gene or overexpression of its negative regulator, murine double minute-2 (MDM2). This event is now considered an essential part of the oncogenic process. Epstein–Barr virus (EBV) is strongly associat...

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Autori principali: Pujals, A, Renouf, B, Robert, A, Chelouah, S, Hollville, É, Wiels, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199720/
https://ncbi.nlm.nih.gov/pubmed/21796156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.67
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