Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation

Cisplatin is widely used for treating various solid tumors. However, this drug produces dose-limiting ototoxicity and nephrotoxicity, which significantly reduce the quality of life of cancer patients. While nephrotoxicity could be alleviated by diuresis, there is currently no approved treatment for...

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Hauptverfasser: Kaur, T, Mukherjea, D, Sheehan, K, Jajoo, S, Rybak, L P, Ramkumar, V
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199718/
https://ncbi.nlm.nih.gov/pubmed/21776018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.63
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