L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission

Dyskinesia is a serious motor complication caused by prolonged administration of l-DOPA to patients affected by Parkinson’s disease. Accumulating evidence indicates that l-DOPA-induced dyskinesia (LID) is primarily caused by the development of sensitized dopamine D1 receptor (D1R) transmission in th...

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Главные авторы: Feyder, Michael, Bonito-Oliva, Alessandra, Fisone, Gilberto
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Research Foundation 2011
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199545/
https://ncbi.nlm.nih.gov/pubmed/22028687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2011.00071
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