L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission

Dyskinesia is a serious motor complication caused by prolonged administration of l-DOPA to patients affected by Parkinson’s disease. Accumulating evidence indicates that l-DOPA-induced dyskinesia (LID) is primarily caused by the development of sensitized dopamine D1 receptor (D1R) transmission in th...

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Autori principali: Feyder, Michael, Bonito-Oliva, Alessandra, Fisone, Gilberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Research Foundation 2011
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199545/
https://ncbi.nlm.nih.gov/pubmed/22028687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2011.00071
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