Transcription Factor Zic2 Inhibits Wnt/β-Catenin Protein Signaling

The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of β-catenin·TCF4-mediated transcription. We show that Z...

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Detalles Bibliográficos
Autores principales: Pourebrahim, Rasoul, Houtmeyers, Rob, Ghogomu, Stephen, Janssens, Sylvie, Thelie, Aurore, Tran, Hong Thi, Langenberg, Tobias, Vleminckx, Kris, Bellefroid, Eric, Cassiman, Jean-Jacques, Tejpar, Sabine
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199516/
https://ncbi.nlm.nih.gov/pubmed/21908606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.242826
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