Transcription Factor Zic2 Inhibits Wnt/β-Catenin Protein Signaling

The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of β-catenin·TCF4-mediated transcription. We show that Z...

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Hlavní autoři: Pourebrahim, Rasoul, Houtmeyers, Rob, Ghogomu, Stephen, Janssens, Sylvie, Thelie, Aurore, Tran, Hong Thi, Langenberg, Tobias, Vleminckx, Kris, Bellefroid, Eric, Cassiman, Jean-Jacques, Tejpar, Sabine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199516/
https://ncbi.nlm.nih.gov/pubmed/21908606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.242826
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