Analysis of Mutations That Dissociate G(2) and Essential S Phase Functions of Human Ataxia Telangiectasia-mutated and Rad3-related (ATR) Protein Kinase

ATR (ataxia telangiectasia-mutated and Rad3-related) contains 16 conserved candidate autophosphorylation sites that match its preferred S/TQ consensus. To determine whether any is functionally important, we mutated the 16 candidate residues to alanine in a single cDNA to create a 16A-ATR mutant. The...

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Hlavní autoři: Nam, Edward A., Zhao, Runxiang, Cortez, David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199479/
https://ncbi.nlm.nih.gov/pubmed/21908846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276113
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