ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1

Glioma is the most common adult primary brain tumor. Its most malignant form, glioblastoma multiforme (GBM), is almost invariably fatal, due in part to the intrinsic resistance of GBM to radiation- and chemotherapy-induced apoptosis. We analyzed B-cell leukemia–2 (Bcl-2) anti-apoptotic proteins in G...

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Main Authors: Day, Bryan W., Stringer, Brett W., Spanevello, Mark D., Charmsaz, Sara, Jamieson, Paul R., Ensbey, Kathleen S., Carter, Jacinta C., Cox, Joanne M., Ellis, Vicky J., Brown, Christopher L., Walker, David G., Inglis, Po L., Allan, Suzanne, Reynolds, Brent A., Lickliter, Jason D., Boyd, Andrew W.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Basic and Translational Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199151/
https://ncbi.nlm.nih.gov/pubmed/21846680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor119
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