A PLACEBO CONTROLLED TRIAL OF MEMANTINE AS AN ADJUNCT TO ORAL NALTREXONE FOR OPIOID DEPENDENCE

BACKGROUND: Preclinical findings suggest that the inhibition of NMDA glutamatergic neurotransmission may have beneficial effects in the treatment of opioid dependence. AIMS: We hypothesized that memantine, a low-potency, uncompetitive NMDA receptor antagonist, would be safe and effective when used a...

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Autors principals: Bisaga, Adam, Sullivan, Maria A., Cheng, Wendy Y., Carpenter, Kenneth M., Mariani, John J, Levin, Frances R., Raby, Wilfrid N., Nunes, Edward V.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199033/
https://ncbi.nlm.nih.gov/pubmed/21715107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2011.05.019
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