Synthesis of [alpha-methyltyrosine-4]angiotensin II: studies of its conformation, pressor activity, and mode of enzymatic degradation.

Modifications in angiotensin II and its antagonistic peptides that should have increased in vivo half-lives but not reduced biological activity were studied by determining the effect of alpha-methylation of the tyrosine in position 4. [alpha-Methyltyrosine-4]angiotensin II, synthesized by the solid-...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Khosla, M C, Stachowiak, K, Smeby, R R, Bumpus, F M, Piriou, F, Lintner, K, Fermandjian, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1981
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319881/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6940144/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.2.757
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