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Synthesis of [alpha-methyltyrosine-4]angiotensin II: studies of its conformation, pressor activity, and mode of enzymatic degradation.

Modifications in angiotensin II and its antagonistic peptides that should have increased in vivo half-lives but not reduced biological activity were studied by determining the effect of alpha-methylation of the tyrosine in position 4. [alpha-Methyltyrosine-4]angiotensin II, synthesized by the solid-...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Khosla, M C, Stachowiak, K, Smeby, R R, Bumpus, F M, Piriou, F, Lintner, K, Fermandjian, S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319881/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6940144/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.2.757
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