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A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors
Dysregulation of the mammalian target of rapamycin (mTOR) signaling has been found in many human cancers, particularly those with loss of the tumor suppressor PTEN. However, mTORC1 inhibitors such as temsirolimus have only modest activity when used alone and may induce acquired resistance by activat...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3198385/ https://ncbi.nlm.nih.gov/pubmed/22039466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026343 |
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