Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores

Rab5 is a small GTPase known to regulate vesicular trafficking during interphase. Here, we show that Rab5 also plays an unexpected role during mitotic progression. RNAi-mediated silencing of Rab5 caused defects in chromosome congression and extensive prometaphase delay, and it correlated with a seve...

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Main Authors: Serio, Gaetana, Margaria, Valentina, Jensen, Sanne, Oldani, Amanda, Bartek, Jiri, Bussolino, Federico, Lanzetti, Letizia
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198334/
https://ncbi.nlm.nih.gov/pubmed/21987812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103516108
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