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Discovery of 2-(4-Methylfuran-2(5H)-ylidene)malononitrile and Thieno[3,2-b]thiophene-2-carboxylic Acid Derivatives as G Protein-Coupled Receptor 35 (GPR35) Agonists

[Image: see text] Screening with dynamic mass redistribution (DMR) assays in a native cell line HT-29 led to identification of two novel series of chemical compounds, 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives, as GPR35 agonists. Of these, 2...

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Main Authors: Deng, Huayun, Hu, Haibei, He, Mingqian, Hu, Jieyu, Niu, Weijun, Ferrie, Ann M., Fang, Ye
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2011
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198121/
https://ncbi.nlm.nih.gov/pubmed/21950657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200999f
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