Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats

OBJECTIVE: Sirtuin 1 (SIRT1) and its activator resveratrol are emerging as major regulators of metabolic processes. We investigate the site of resveratrol action on glucose metabolism and the contribution of SIRT1 to these effects. Because the arcuate nucleus in the mediobasal hypothalamus (MBH) pla...

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Détails bibliographiques
Auteurs principaux: Knight, Colette M., Gutierrez-Juarez, Roger, Lam, Tony K.T., Arrieta-Cruz, Isabel, Huang, Loli, Schwartz, Gary, Barzilai, Nir, Rossetti, Luciano
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2011
Sujets:
Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198094/
https://ncbi.nlm.nih.gov/pubmed/21896928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0987
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