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Temperature-sensitive RNA polymerase mutants of a picornavirus.

Temperature-sensitive (ts) RNA polymerase mutants of a picornavirus are reported. Two foot-and-mouth disease virus (FMDV) mutants designated ts 22 and ts 115 have been characterized. As judged by isoelectric focusing, both have charge alterations in P56a, the FMDV RNA polymerase protein. Virus RNA s...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lowe, P A, King, A M, McCahon, D, Brown, F, Newman, J W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319808/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6270678/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.7.4448
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