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Dominant-Negative Mechanism of Leukemogenic PAX5 Fusions
PAX5 encodes a master regulator of B-cell development. It fuses to other genes associated with acute lymphoblastoid leukemia (ALL). These fusion products are potent dominant-negative (DN) inhibitors of wild-type PAX5 resulting in a blockade of B-cell differentiation. Here, we show that multimerizati...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197879/ https://ncbi.nlm.nih.gov/pubmed/21765475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.291 |
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