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Isotope-Coded Dimethyl Tagging for Differential Quantification of Posttranslational Protein Carbonylation by 4-Hydroxy-2-nonenal, an End-Product of Lipid Peroxidation
Peroxidation of cellular membrane lipids, rich in polyunsaturated fatty acids, generates electrophilic, α,β-unsaturated aldehydes such as 4-hydroxy-2-nonenal (HNE). HNE is a highly reactive and cytotoxic molecule that can react with the nucleophilic sites in proteins causing posttranslational modifi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197809/ https://ncbi.nlm.nih.gov/pubmed/22012663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jms.1978 |
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