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Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling
In recent years, 4-hydroxy-2-nonenal (4-HNE) has emerged as an important second messenger in cell cycle signaling. Here we demonstrate that 4-HNE induces signaling for apoptosis via both, the Fas mediated extrinsic and the p53 mediated intrinsic pathways in HepG2 cells. 4-HNE induces Fas-mediated DI...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957295/ https://ncbi.nlm.nih.gov/pubmed/20565132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100517x |
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