Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

In recent years, 4-hydroxy-2-nonenal (4-HNE) has emerged as an important second messenger in cell cycle signaling. Here we demonstrate that 4-HNE induces signaling for apoptosis via both, the Fas mediated extrinsic and the p53 mediated intrinsic pathways in HepG2 cells. 4-HNE induces Fas-mediated DI...

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Main Authors: Chaudhary, Pankaj, Sharma, Rajendra, Sharma, Abha, Vatsyayan, Rit, Yadav, Sushma, Singhal, Sharad S., Rauniyar, Navin, Prokai, Laszlo, Awasthi, Sanjay, Awasthi, Yogesh C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957295/
https://ncbi.nlm.nih.gov/pubmed/20565132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100517x
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