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Increased Expression of Cdc2 Inhibits Transport Function of RLIP76 and Promotes Apoptosis

RLIP76 is a stress-responsive glutathione-electrophile-conjugates (GS-E) and drugs transporter which is over-expressed in different types of cancers. Cdc2 is a cell-cycle check point control kinase which has been shown to bind to RLIP76 during mitosis, such that endocytosis is inhibited. In present...

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Detalhes bibliográficos
Main Authors: Singhal, Sharad S., Yadav, Sushma, Vatsyayan, Rit, Chaudhary, Pankaj, Borvak, Jozef, Singhal, Jyotsana, Awasthi, Sanjay
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721022/
https://ncbi.nlm.nih.gov/pubmed/19375851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2009.03.033
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