Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis

Mycobacterium tuberculosis is the causative agent of human tuberculosis (TB). Mycobacterial secretory protein ESAT-6 induces MMP-9 in epithelial cells neighboring infected macrophages. MMP-9 then enhances recruitment of uninfected macrophages, which contribute to nascent granuloma maturation and bac...

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Detalhes bibliográficos
Main Authors: Shiryaev, Sergey A., Cieplak, Piotr, Aleshin, Alexander E., Sun, Qing, Zhu, Wenhong, Motamedchaboki, Khatereh, Sloutsky, Alexander, Strongin, Alex Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197701/
https://ncbi.nlm.nih.gov/pubmed/21752195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2011.08244.x
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