Ensemble-Based Computational Approach Discriminates Functional Activity of p53 Cancer and Rescue Mutants

The tumor suppressor protein p53 can lose its function upon single-point missense mutations in the core DNA-binding domain (“cancer mutants”). Activity can be restored by second-site suppressor mutations (“rescue mutants”). This paper relates the functional activity of p53 cancer and rescue mutants...

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Detalhes bibliográficos
Main Authors: Demir, Özlem, Baronio, Roberta, Salehi, Faezeh, Wassman, Christopher D., Hall, Linda, Hatfield, G. Wesley, Chamberlin, Richard, Kaiser, Peter, Lathrop, Richard H., Amaro, Rommie E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197647/
https://ncbi.nlm.nih.gov/pubmed/22028641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002238
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