Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats

BACKGROUND: In mammals, hair cells do not undergo spontaneous regeneration when they are damaged and result in permanent hearing loss. Previous studies in cultured Organ of Corti dissected from neonatal animals have shown that both DAPT (r-secretase inhibitor in the Notch signal pathway) treatment a...

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Detalhes bibliográficos
Main Authors: Zhao, Li-Dong, Guo, Wei-Wei, Lin, Chang, Li, Li-Xian, Sun, Jian-He, Wu, Nan, Ren, Li-Li, Li, Xin-Xin, Liu, Hui-Zhan, Young, Wie-Yen, Gao, Wei-Qiang, Yang, Shi-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197578/
https://ncbi.nlm.nih.gov/pubmed/22028767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023729
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