Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats

BACKGROUND: In mammals, hair cells do not undergo spontaneous regeneration when they are damaged and result in permanent hearing loss. Previous studies in cultured Organ of Corti dissected from neonatal animals have shown that both DAPT (r-secretase inhibitor in the Notch signal pathway) treatment a...

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Bibliographic Details
Main Authors: Zhao, Li-Dong, Guo, Wei-Wei, Lin, Chang, Li, Li-Xian, Sun, Jian-He, Wu, Nan, Ren, Li-Li, Li, Xin-Xin, Liu, Hui-Zhan, Young, Wie-Yen, Gao, Wei-Qiang, Yang, Shi-Ming
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197578/
https://ncbi.nlm.nih.gov/pubmed/22028767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023729
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