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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

The functional analysis of missense mutations can be complicated by the presence in the cell of the endogenous protein. Structure-function analyses of the BRCA1 have been complicated by the lack of a robust assay for the full length BRCA1 protein and the difficulties inherent in working with cell li...

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Bibliografiske detaljer
Main Authors: Parvin, Jeffrey, Chiba, Natsuko, Ransburgh, Derek
Format: Artigo
Sprog:Inglês
Udgivet: MyJove Corporation 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197403/
https://ncbi.nlm.nih.gov/pubmed/21372787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/2468
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