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Ageing of α-chymotrypsin: Cannibalistic and hydroxide ion reactions

The loss of catalytic activity (irreversible denaturation) of α-chymotrypsin (EC 3.4.21.1) as a function of pH between 6 and 13 is described. Around neutrality the irreversible denaturation is second order with respect to enzyme. At high pH, the irreversible denaturation is first order with respect...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Wu, Hua-Lin, Wastell, Andrea, Bender, Myron L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1981
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319737/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/16593051/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.7.4116
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