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Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.

We found that two markers of differentiation, tyrosinase (monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, EC 1.14.18.1) activity and melanin synthesis, are induced by diazepam in B16/C3 mouse melanoma cells. We also demonstrated high-affinity binding sites for [3H]diazepam in these cells b...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Matthew, E, Laskin, J D, Zimmerman, E A, Weinstein, I B, Hsu, K C, Engelhardt, D L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319688/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6267610/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.6.3935
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