Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.

We found that two markers of differentiation, tyrosinase (monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, EC 1.14.18.1) activity and melanin synthesis, are induced by diazepam in B16/C3 mouse melanoma cells. We also demonstrated high-affinity binding sites for [3H]diazepam in these cells b...

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I whakaputaina i:	Proc Natl Acad Sci U S A
Ngā kaituhi matua:	Matthew, E, Laskin, J D, Zimmerman, E A, Weinstein, I B, Hsu, K C, Engelhardt, D L
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	National Academy of Sciences 1981
Ngā marau:	Research Article
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319688/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6267610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.6.3935
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Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.

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