The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-L-ornithine amide (o-F-amidine) and N α-(2-carboxyl)benzoyl-N(5)-(2-Chloro-1-iminoethyl)-L-ornithine amide (o-Cl-amidine) as second generation Protein Arginine Deiminase (PAD) inhibitors.

Protein Arginine Deiminase (PAD) activity is upregulated in a number of human diseases, including rheumatoid arthritis, ulcerative colitis, and cancer. These enzymes, there are five in humans (PADs 1-4 and 6) regulate gene transcription, cellular differentiation, and the innate immune response. Buil...

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Autori principali: Causey, Corey P., Jones, Justin E., Slack, Jessica L, Kamei, Daisuke, Jones, Larry E., Subramanian, Venkataraman, Knuckley, Bryan, Ebrahimi, Pedram, Chumanevich, Alexander A., Luo, Yuan, Hashimoto, Hiroshi, Sato, Mamoru, Hofseth, Lorne J., Thompson, Paul R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196593/
https://ncbi.nlm.nih.gov/pubmed/21882827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2008985
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