The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-L-ornithine amide (o-F-amidine) and N α-(2-carboxyl)benzoyl-N(5)-(2-Chloro-1-iminoethyl)-L-ornithine amide (o-Cl-amidine) as second generation Protein Arginine Deiminase (PAD) inhibitors.

Protein Arginine Deiminase (PAD) activity is upregulated in a number of human diseases, including rheumatoid arthritis, ulcerative colitis, and cancer. These enzymes, there are five in humans (PADs 1-4 and 6) regulate gene transcription, cellular differentiation, and the innate immune response. Buil...

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Detalhes bibliográficos
Main Authors: Causey, Corey P., Jones, Justin E., Slack, Jessica L, Kamei, Daisuke, Jones, Larry E., Subramanian, Venkataraman, Knuckley, Bryan, Ebrahimi, Pedram, Chumanevich, Alexander A., Luo, Yuan, Hashimoto, Hiroshi, Sato, Mamoru, Hofseth, Lorne J., Thompson, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196593/
https://ncbi.nlm.nih.gov/pubmed/21882827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2008985
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