Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues

EV71 is the primary pathogenic cause of hand-foot-mouth disease (HFMD), but an effective antiviral drug currently is unavailable. Rupintrivir, an inhibitor against human rhinovirus (HRV), has potent antiviral activities against EV71. We determined the high-resolution crystal structures of the EV71 3...

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Bibliographic Details
Main Authors: Wang, Jing, Fan, Tingting, Yao, Xue, Wu, Zhiqiang, Guo, Li, Lei, Xiaobo, Wang, Jianwei, Wang, Meitian, Jin, Qi, Cui, Sheng
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196404/
https://ncbi.nlm.nih.gov/pubmed/21813612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05107-11
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