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HIV ENV Glycoprotein-mediated Bystander Apoptosis Depends on Expression of the CCR5 Co-receptor at the Cell Surface and ENV Fusogenic Activity

HIV-1 infections lead to a progressive depletion of CD4 cells culminating in AIDS. The coreceptor usage by HIV varies from CCR5 (R5) tropic early in infection to CXCR4 (X4) tropic in later infections. Although the coreceptor switch from R5 to X4 tropic HIV is well associated with progression to AIDS...

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Библиографические подробности
Главные авторы: Joshi, Anjali, Nyakeriga, Alice M., Ravi, Revathi, Garg, Himanshu
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196103/
https://ncbi.nlm.nih.gov/pubmed/21859712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.281659
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