Ligand-dependent perturbation of the conformational ensemble for the GPCR beta2 adrenergic receptor revealed by HDX

Mechanism of G-protein coupled receptor (GPCR) activation and their modulation by functionally distinct ligands remains elusive. Using the technique of amide hydrogen/deuterium exchange coupled with mass spectrometry we examined the ligand-induced changes in conformational states and stability withi...

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Bibliografski detalji
Glavni autori: West, Graham M., Chien, Ellen Y. T., Katritch, Vsevolod, Gatchalian, Jovylyn, Chalmers, Michael J., Stevens, Raymond C., Griffin, Patrick R.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196059/
https://ncbi.nlm.nih.gov/pubmed/21889352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.08.001
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