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Identifying conformational changes of the β(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators

The new β(2) Adrenoceptor (β(2)AR) crystal structures provide a high-resolution snapshot of receptor interactions with two particular partial inverse agonists, (−)-carazolol and timolol. However, both experimental and computational studies of GPCR structure are significantly complicated by the exist...

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Detalhes bibliográficos
Main Authors: Reynolds, Kimberly A., Katritch, Vsevolod, Abagyan, Ruben
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667566/
https://ncbi.nlm.nih.gov/pubmed/19148767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-008-9257-9
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