Hyperpolarized (13)C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma

Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor in humans. Because the phosphatidylinositol-3-kinase (PI3K) signaling pathway is activated in more than 88% of GBM, new drugs which target this pathway, such as the mTOR inhibitor Everolimus, are currently in clinical tri...

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Hauptverfasser: Chaumeil, Myriam M., Ozawa, Tomoko, Park, IlWoo, Scott, Kristen, James, C. David, Nelson, Sarah J., Ronen, Sabrina M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196046/
https://ncbi.nlm.nih.gov/pubmed/21807103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2011.07.034
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