Detection of Early Response to Temozolomide Treatment in Brain Tumors Using Hyperpolarized (13)C MR Metabolic Imaging

PURPOSE: To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. MATERIALS AND METHODS: Twenty athymic rats with intracranial implantation of human glioblastoma cells...

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Udgivet i:J Magn Reson Imaging
Main Authors: Park, Ilwoo, Bok, Robert, Ozawa, Tomoko, Phillips, Joanna J., James, C. David, Vigneron, Daniel B., Ronen, Sabrina M., Nelson, Sarah J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983457/
https://ncbi.nlm.nih.gov/pubmed/21590996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmri.22563
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