Quantitative pharmacological analysis of antagonist binding kinetics at CRF(1) receptors in vitro and in vivo

BACKGROUND AND PURPOSE: A series of novel non-peptide corticotropin releasing factor type-1 receptor (CRF(1)) antagonists were found to display varying degrees of insurmountable and non-competitive behaviour in functional in vitro assays. We describe how we attempted to relate this behaviour to liga...

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Main Authors: Ramsey, Simeon J, Attkins, Neil J, Fish, Rebecca, van der Graaf, Piet H
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2011
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195921/
https://ncbi.nlm.nih.gov/pubmed/21449919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01390.x
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