Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle

BACKGROUND AND PURPOSE: Platelet-derived growth factor (PDGF) modulates the airway smooth muscle (ASM) ‘contractile’ phenotype to a more ‘proliferative’ phenotype, resulting in increased proliferation and reduced contractility. Such phenotypic modulation may contribute to airway remodelling in asthm...

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Hlavní autoři: Roscioni, Sara S, Prins, Alwin G, Elzinga, Carolina RS, Menzen, Mark H, Dekkers, Bart GJ, Halayko, Andrew J, Meurs, Herman, Maarsingh, Harm, Schmidt, Martina
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2011
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195918/
https://ncbi.nlm.nih.gov/pubmed/21426315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01354.x
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