PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells

BACKGROUND: Airway smooth muscle contributes to the pathogenesis of pulmonary diseases by secreting inflammatory mediators such as interleukin-8 (IL-8). IL-8 production is in part regulated via activation of G(q)-and G(s)-coupled receptors. Here we study the role of the cyclic AMP (cAMP) effectors p...

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Detalhes bibliográficos
Main Authors: Roscioni, Sara S, Kistemaker, Loes EM, Menzen, Mark H, Elzinga, Carolina RS, Gosens, Reinoud, Halayko, Andrew J, Meurs, Herman, Schmidt, Martina
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764632/
https://ncbi.nlm.nih.gov/pubmed/19788733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-10-88
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