A Helix Heterodimer in a Lipid Bilayer: Prediction of the Structure of an Integrin Transmembrane Domain via Multiscale Simulations

Dimerization of transmembrane (TM) α helices of membrane receptors plays a key role in signaling. We show that molecular dynamics simulations yield models of integrin TM helix heterodimers, which agree well with available NMR structures. We use a multiscale simulation approach, combining coarse-grai...

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Päätekijät: Kalli, Antreas C., Hall, Benjamin A., Campbell, Iain D., Sansom, Mark S.P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195670/
https://ncbi.nlm.nih.gov/pubmed/22000516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.07.014
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