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Access to the Complement Factor B Scissile Bond Is Facilitated by Association of Factor B with C3b Protein
Factor B is a zymogen that carries the catalytic site of the complement alternative pathway C3 convertase. During convertase assembly, factor B associates with C3b and Mg(2+) forming a pro-convertase C3bB(Mg(2+)) that is cleaved at a single factor B site by factor D. In free factor B, a pair of salt...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3195642/ https://ncbi.nlm.nih.gov/pubmed/21862585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.263418 |
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