The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders. All Sez6 family members contain 2-3 CUB domains and 5...

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Publicado en:Front Immunol
Autores principales: Qiu, Wen Q., Luo, Shaopeiwen, Ma, Stefanie A., Saminathan, Priyanka, Li, Herman, Gunnersen, Jenny M., Gelbard, Harris A., Hammond, Jennetta W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081827/
https://ncbi.nlm.nih.gov/pubmed/33936031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.607641
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